Article
Diagnostic value of investigating GNAS mutations in fibro-osseous lesions: a retrospective study of 91 cases of fibrous dysplasia and 40 other fibro-osseous lesions.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jul 2013
Tabareau-Delalande Flore, Collin Christine, Gomez-Brouchet Anne, Decouvelaere Anne-Valérie, Bouvier Corinne, Larousserie Frédérique, Marie Béatrice, Delfour Christophe, Aubert Sébastien, Rosset Philippe, de Muret Anne, Pagès Jean-Christophe, de Pinieux Gonzague
Abstract excerpt
GNAS (guanine nucleotide-binding protein/α-subunit) mutations that induce the activation of G-protein α-subunit participate in the pathogenesis of fibrous dysplasia. The aim of this study was to evaluate the sensitivity and specificity of GNAS mutations in fibrous dysplasia and other fibro-osseous lesions, to assess the value of investigating this mutation in the diagnosis of fibro-osseous lesions. We studied 91...
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