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Article

Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a.

British journal of pharmacology - 1 Oct 2015

Saez Natalie J, Deplazes Evelyne, Cristofori-Armstrong Ben, Chassagnon Irène R, Lin Xiaozhen, Mobli Mehdi, Mark Alan E, Rash Lachlan D, King Glenn F

Abstract excerpt

BACKGROUND AND PURPOSE: The spider-venom peptide PcTx1 is the most potent and selective inhibitor of acid-sensing ion channel (ASIC) 1a. It has centrally acting analgesic activity and is neuroprotective in rodent models of ischaemic stroke. Understanding the molecular details of the PcTx1 : ASIC1a interaction should facilitate development of therapeutically useful ASIC1a modulators. Previously, we showed that...

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Identifiers

PMID: 26248594
DOI: 10.1111/bph.13267
PMCID: PMC4621980

Genes

ASIC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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