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Polyploid giant cancer cells and cancer progression

5 Oct 2022

Abstract excerpt

PGCCs) are an important feature of cellular atypia, the detailed mechanisms of their formation and function remain unclear. PGCCs were previously thought to be derived from repeated mitosis/cytokinesis failure, with no intrinsic ability to proliferate and divide. However, recently, PGCCs have been confirmed to have cancer stem cell (CSC)-like characteristics, and generate progeny cells through asymmetric...

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PMID: 36274852
DOI: 10.3389/fcell.2022.1017588

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