Article
An insertion/deletion polymorphism at the microRNA-122 binding site in the interleukin-1α 3'-untranslated region is associated with a risk for osteoarthritis.
Molecular medicine reports - 1 Oct 2015
Yang Fan, Hu Anfeng, Zhao Dewei, Guo Lin, Yang Lei, Wang Benjie, Tian Fengde, Liu Baoyi, Huang Shibo, Xie Hui
Abstract excerpt
Polymorphisms located at microRNA (miRNA) binding sites may affect the expression of genes. The present study aimed to identify the association between an insertion/deletion (Ins/Del) polymorphism (rs3783553) in the 3'‑untranslated region (3'‑UTR) of interleukin‑1α (IL‑1A) and the risk for osteoarthritis (OA). Using a luciferase reporter system, IL‑1A was identified in the present study as an effective target...
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