An insertion/deletion polymorphism at miRNA-122 binding site in the IL1A is associated with a reduced risk of cervical squamous cell carcinoma.

doi:10.1089/gtmb.2015.0015

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An insertion/deletion polymorphism at miRNA-122 binding site in the IL1A is associated with a reduced risk of cervical squamous cell carcinoma.

Genetic testing and molecular biomarkers - 1 Jun 2015

Huang Juan, Ni Shanshan, Li Danqing, He Yuedong

Abstract excerpt

OBJECTIVE: Previous studies have shown that miRNA plays a key role in cervical carcinogenesis. Interleukin (IL)-1α can promote tumor growth, invasion, migration, and angiogenesis. An insertion/deletion polymorphism (rs3783553) in the IL1A 3' untranslated region may disrupt a binding site for miR-122 and miR-378 and thus change the transcription of IL-1α. The purpose of this study was to evaluate the association...

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PMID: 25955681
DOI: 10.1089/gtmb.2015.0015

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