Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Secretory leukocyte protease inhibitor inhibits expression of polymeric immunoglobulin receptor via the NF-κB signaling pathway.

Molecular immunology - 1 Oct 2015

Mikami Yoshikazu, Iwase Takashi, Komiyama Yusuke, Matsumoto Naoyuki, Oki Hidero, Komiyama Kazuo

Abstract excerpt

Polymeric immunoglobulin receptor (pIgR) plays an important role in mucosal immune systems. Secretory immunoglobulin A, composed of secretory component of pIgR and a dimeric form of immunoglobulin A, is secreted on mucosal surfaces and serves as a biological defense factor. pIgR gene expression is reportedly induced by activation of the transcription factor nuclear factor (NF)-κB. On the other hand, secretory...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gastrointestinal Tract
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Knockout Techniques

Share to HT29 Cells

Share to NF-kappa B

Share to Recombinant Proteins

Share to RNA, Messenger

Share to Salivary Glands

Source

Identifiers

PMID: 26239418
DOI: 10.1016/j.molimm.2015.07.021

Genes

SLPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Secretory leukocyte protease inhibitor inhibits expression of polymeric immunoglobulin receptor via the NF-κB signaling pathway.PMID 26239418Read ↗

Secretory Cells Are the Primary Source of pIgR in Small AirwaysSemantic proximity Read ↗

Secretory Leukocyte Protease Inhibitor Mediates Proliferation of Human Endometrial Epithelial Cells by Positive and Negative Regulation of Growth-associated GenesSemantic proximity Read ↗

The Granzyme B Inhibitor, Protease Inhibitor 9, Is Mainly Expressed by Dendritic Cells and at Immune-Privileged SitesSemantic proximity Read ↗

A recombinant human SLPI variant suppresses the formation of neutrophil extracellular traps at low concentrations in vitro.Semantic proximity Read ↗

The Serine Protease Autotransporters TagB, TagC, and Sha from Extraintestinal Pathogenic Escherichia coli Are Internalized by Human Bladder Epithelial Cells and Cause Actin Cytoskeletal Disruption.Semantic proximity Read ↗

Multiple transcription factors in 5'-flanking region of human polymeric Ig receptor control its basal expression.Semantic proximity Read ↗

Ectodomains 3 and 4 of Human Polymeric Immunoglobulin Receptor (hpIgR) Mediate Invasion of Streptococcus pneumoniae into the EpitheliumSemantic proximity Read ↗

Upstream stimulatory factor but not c-Myc enhances transcription of the human polymeric immunoglobulin receptor gene.Semantic proximity Read ↗

Potent antimycobacterial activity of mouse secretory leukocyte protease inhibitor.Semantic proximity Read ↗

Expression of the secretory leukoprotease inhibitor gene in epithelial cells.Semantic proximity Read ↗

Polymeric IgR knockout mice are more susceptible to mycobacterial infections in the respiratory tract than wild-type mice.Semantic proximity Read ↗

Human neutrophil defensins and secretory leukocyte proteinase inhibitor in squamous metaplastic epithelium of bronchial airways.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.