Expression of the secretory leukoprotease inhibitor gene in epithelial cells.

doi:10.1172/JCI115255

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Article

Expression of the secretory leukoprotease inhibitor gene in epithelial cells.

The Journal of clinical investigation - 1 Jun 1991

Abe T, Kobayashi N, Yoshimura K, Trapnell B C, Kim H, Hubbard R C, Brewer M T, Thompson R C, Crystal R G

Abstract excerpt

The secretory leukoprotease inhibitor (SLPI) gene codes for a 12-kD protein that within the lung protects the airway epithelium from neutrophil elastase. Screening of 228 alleles in 114 individuals for sequence differences by RNase protection of genomic DNA revealed no detectable polymorphisms in SLPI gene exons II-IV. SLPI gene expression in the lung was demonstrated by identifying SLPI mRNA transcripts in...

Topics

Base Sequence
Blotting, Northern
Bronchi
Cells, Cultured
Epithelium
Exons
Gene Expression
Gene Expression Regulation
Genes
Humans
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Oligonucleotides

Polymerase Chain Reaction

Proteinase Inhibitory Proteins, Secretory

Proteins

RNA, Messenger

Regulatory Sequences, Nucleic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 1674946
DOI: 10.1172/JCI115255
PMCID: PMC296981

Genes

SLPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1674946-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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