Article

Boosting Toll-like receptor 4 signaling enhances the therapeutic outcome of antibiotic therapy in pneumococcal pneumonia

2020-02-21

Abstract excerpt

<h4>ABSTRACT</h4> The emergence and spread of antibiotic resistance emphasize the need for alternative treatment strategies against bacterial infections. Boosting the host innate immunity is not only readily deployable in most individuals but can also mobilize many different antibacterial defenses. This study tested the hypothesis whereby stimulation of the innate immune receptor Toll-like receptor 4 (TLR4) can b...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1db952e6-fd45-5024-87a6-64822b05be62
DOI: 10.1101/2020.02.18.955500

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Boosting Toll-like receptor 4 signaling enhances the therapeutic outcome of antibiotic therapy in pneumococcal pneumoniaDOI 10.1101/2020.02.18.955500Read

Immunostimulation with Macrophage-Activating Lipopeptide-2 Increased Survival in Murine PneumoniaSemantic proximity Read

Nasopharyngeal colonisation by <i>Streptococcus pneumoniae</i> enhances host anti-viral responses to respiratory virus infectionSemantic proximity Read

Overview of community-acquired pneumonia and the role of inflammatory mechanisms in the immunopathogenesis of severe pneumococcal disease.Semantic proximity Read

Biological Effects of Corticosteroids on Pneumococcal Pneumonia in Mice and HumansSemantic proximity Read

PcpA Promotes Higher Levels of Infection and Modulates Recruitment of Myeloid-Derived Suppressor Cells during Pneumococcal Pneumonia.Semantic proximity Read

Synergy between the Host Immune System and Bacteriophage Is Essential for Successful Phage Therapy against an Acute Respiratory Pathogen.Semantic proximity Read

A multiple comorbidities mouse model to assess atherosclerosis progression following lung infection in <i>ApoE</i> deficient miceSemantic proximity Read

<i>Streptococcus pneumoniae</i> evades host cell phagocytosis and limits host mortality through its cell wall anchoring protein PfbASemantic proximity Read

Pneumolysin suppresses the initial macrophage pro‐inflammatory response to Streptococcus pneumoniaeSemantic proximity Read

Comparative transcriptional profiling of the lung reveals shared and distinct features of Streptococcus pneumoniae and influenza A virus infection.Semantic proximity Read

Phage therapy potentiates second-line antibiotic treatment against pneumonic plagueSemantic proximity Read

Toll-like receptor-4 agonist in post-haemorrhage pneumonia: role of dendritic and natural killer cells.Semantic proximity Read