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Article

Genetic variants in 6-mercaptopurine pathway as potential factors of hematological toxicity in acute lymphoblastic leukemia patients.

Pharmacogenomics - 1 Jan 2015

Hareedy Mohammad Salem, El Desoky Ehab S, Woillard Jean-Baptiste, Thabet Romany Helmy, Ali Amany Mohamad, Marquet Pierre, Picard Nicolas

Abstract excerpt

AIM: We investigated the associations between variants in genes coding for enzymes and transporters related to the 6-mercaptopurine pathway and clinical outcomes in pediatric patients with acute lymphoblastic leukemia. MATERIALS & METHODS: Statistical association between gender, age and genotypes of selected SNPs, and the risks of hematological toxicity and relapse were investigated using a Cox proportional...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26237184
DOI: 10.2217/PGS.15.62

Genes

ABCC4
IMPDH1
ITPA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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