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Article

Association of ITPA genotype with event-free survival and relapse rates in children with acute lymphoblastic leukemia undergoing maintenance therapy.

PloS one - 1 Jan 2014

Smid Alenka, Karas-Kuzelicki Natasa, Milek Miha, Jazbec Janez, Mlinaric-Rascan Irena

Abstract excerpt

Although the treatment of acute lymphoblastic leukemia (ALL) has improved significantly over recent decades, failure due to treatment-related toxicities and relapse of the disease still occur in about 20% of patients. This retrospective study included 308 pediatric ALL patients undergoing maintenance therapy and investigated the effects of genetic variants of enzymes involved in the 6-mercaptopurine (6-MP)...

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Source

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Identifiers

PMID: 25303517
DOI: 10.1371/journal.pone.0109551
PMCID: PMC4193781

Genes

ITPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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