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Laminin isoforms in human embryonic stem cells: synthesis, receptor usage and growth support

29 Dec 2008

Abstract excerpt

To reveal the functional intrinsic niche of human embryonic stem cells (hESC) we examined the production of basement membrane (BM) proteins and the presence of their receptors in feeder-free cell culture conditions. In addition, we investigated binding of hESCs to purified human BM proteins and identified the receptors mediating these contacts. Also, we tested whether purified human laminin (Lm) isoforms have a...

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PMID: 19397785
DOI: 10.1111/j.1582-4934.2008.00643.x

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