Article
Arginine 112 is involved in HCV translation modulation by NS5A domain I.
Biochemical and biophysical research communications - 11 Sept 2015
Hoffman Brett, Shi Qing, Liu Qiang
Abstract excerpt
HCV NS5A has three domains, which have multiple roles in the viral life cycle. We previously found that NS5A is able to down-regulate HCV RNA translation through a mechanism requiring the polyU/UC region within the viral 3'UTR to which NS5A binds. In this study, we further investigated the role of domain I in modulating viral translation. Using a series of deletion and substitution mutants, we identified a number...
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