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Article

Inhibition of HCV translation by disrupting the structure and interactions of the viral CRE and 3' X-tail.

Nucleic acids research - 11 Mar 2015

Tuplin Andrew, Struthers Madeleine, Cook Jonathan, Bentley Kirsten, Evans David J

Abstract excerpt

A phylogenetically conserved RNA structure within the NS5B coding region of hepatitis C virus functions as a cis-replicating element (CRE). Integrity of this CRE, designated SL9266 (alternatively 5BSL3.2), is critical for genome replication. SL9266 forms the core of an extended pseudoknot, designated SL9266/PK, involving long distance RNA-RNA interactions between unpaired loops of SL9266 and distal regions of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25712095
DOI: 10.1093/nar/gkv142
PMCID: PMC4357731

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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