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Article

Modeling the Manipulation of Natural Populations by the Mutagenic Chain Reaction.

Genetics - 1 Oct 2015

Unckless Robert L, Messer Philipp W, Connallon Tim, Clark Andrew G

Abstract excerpt

The use of recombinant genetic technologies for population manipulation has mostly remained an abstract idea due to the lack of a suitable means to drive novel gene constructs to high frequency in populations. Recently Gantz and Bier showed that the use of CRISPR/Cas9 technology could provide an artificial drive mechanism, the so-called mutagenic chain reaction (MCR), which could lead to rapid fixation of even a...

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Identifiers

PMID: 26232409
DOI: 10.1534/genetics.115.177592
PMCID: PMC4596658

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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