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Article

Role of genetic variant A-204C of cholesterol 7alpha-hydroxylase (CYP7A1) in susceptibility to gallbladder cancer.

Molecular genetics and metabolism - 1 May 2008

Srivastava Anvesha, Pandey Sachchida Nand, Choudhuri Gourdas, Mittal Balraj

Abstract excerpt

Gallbladder carcinoma (GBC) usually arises in the background of gallstone disease. Cholesterol 7alpha-hydroxylase (CYP7A1) is a rate-limiting enzyme for cholesterol catabolism and bile acid synthesis. A-204C genetic polymorphism in CYP7A1 may influence gene expression and thus affect the risk of gallstone disease and GBC. We aimed to study the association of A-204C variation of CYP7A1 gene promoter polymorphism...

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PMID: 18178499
DOI: 10.1016/j.ymgme.2007.11.014

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