Article
High-Density Genotypes of Inbred Mouse Strains: Improved Power and Precision of Association Mapping.
G3 (Bethesda, Md.) - 28 Jul 2015
Rau Christoph D, Parks Brian, Wang Yibin, Eskin Eleazar, Simecek Petr, Churchill Gary A, Lusis Aldons J
Abstract excerpt
Human genome-wide association studies have identified thousands of loci associated with disease phenotypes. Genome-wide association studies also have become feasible using rodent models and these have some important advantages over human studies, including controlled environment, access to tissues for molecular profiling, reproducible genotypes, and a wide array of techniques for experimental validation....
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