Article
Actn2 defects accelerates H9c2 hypertrophy via ERK phosphorylation under chronic stress.
Genes & genomics - 1 Sept 2024
Wang Kang, Wang Ye, Wan Hua, Wang Jie, Hu Li, Huang Shuainan, Sheng Mingchen, Wu Jiayi, Han Xing, Yu Youjia, Chen Peng, Chen Feng
Abstract excerpt
BACKGROUND: In humans, ACTN2 mutations are identified as highly relevant to a range of cardiomyopathies such as DCM and HCM, while their association with sudden cardiac death has been observed in forensic cases. Although ACTN2 has been shown to regulate sarcomere Z-disc organization, a causal relationship between ACTN2 dysregulation and cardiomyopathies under chronic stress has not yet been investigated....
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