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Article

Differential gene methylation in paired glioblastomas suggests a role of immune response pathways in tumor progression.

Journal of neuro-oncology - 1 Sept 2015

Alentorn Agustí, Durán-Peña Alberto, Malousi Andigoni, Marie Yannick, Mokhtari Karima, Sanson Marc, Hoang-Xuan Khê, Delattre Jean-Yves, Idbaih Ahmed, Vecht Charles

Abstract excerpt

DNA and histone methylation are post-transcriptional modifications that have been recently described in gliomas. Indeed, glioma CpG island hypermethylated phenotype has been identified as prognostic biomarker and as a surrogate marker of IDH1/2 mutations. However, the role of DNA methylation in glioblastoma progression is unknown. We sought to analyze DNA methylation levels in paired (initial and recurrent)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26224161
DOI: 10.1007/s11060-015-1869-z

Genes

IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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