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Article

Mean global DNA methylation serves as independent prognostic marker in IDH-wildtype glioblastoma

11 Oct 2023

Abstract excerpt

BACKGROUND: The IDH-wildtype glioblastoma (GBM) patients have a devastating prognosis. Here, we analyzed the potential prognostic value of global DNA methylation of the tumors. METHODS: DNA methylation of 492 primary samples and 31 relapsed samples, each treated with combination therapy, and of 148 primary samples treated with radiation alone were compared with patient survival. We determined the mean methylation...

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PMID: 37818983
DOI: 10.1093/neuonc/noad197

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