The impact of an inosine triphosphate pyrophosphatase genotype on bilirubin increase in chronic hepatitis C patients treated with simeprevir, pegylated interferon plus ribavirin.

doi:10.1007/s00535-015-1105-9

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Article

The impact of an inosine triphosphate pyrophosphatase genotype on bilirubin increase in chronic hepatitis C patients treated with simeprevir, pegylated interferon plus ribavirin.

Journal of gastroenterology - 1 Mar 2016

Tahata Yuki, Hiramatsu Naoki, Oze Tsugiko, Morishita Naoki, Harada Naoki, Yamada Ryoko, Yakushijin Takayuki, Mita Eiji, Hagiwara Hideki, Yamada Yukinori, Ito Toshifumi, Hijioka Taizo, Inada Masami, Katayama Kazuhiro, Tamura Shinji, Yoshihara Harumasa, Inoue Atsuo, Imai Yasuharu, Irishio Keiko, Kato Michio, Hikita Hayato, Sakamori Ryotaro, Miyagi Takuya, Yoshida Yuichi, Tatsumi Tomohide, Hamasaki Toshimitsu, Hayashi Norio, Takehara Tetsuo

Abstract excerpt

BACKGROUND: Hyperbilirubinemia, mild or moderate, is a commonly observed laboratory abnormality in chronic hepatitis C patients treated with simeprevir with pegylated interferon (Peg-IFN) plus ribavirin. In this prospective, multicenter study, we aimed to investigate the clinical features and factors associated with bilirubin increases during the therapy. METHODS: A total of 192 patients with chronic hepatitis C...

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PMID: 26223482
DOI: 10.1007/s00535-015-1105-9

Genes

ITPA

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