Article
Correlation between polymorphism in the inosine triphosphatase and the reductions in hemoglobin concentration and ribavirin dose during sofosbuvir and ribavirin therapy.
Journal of gastroenterology and hepatology - 1 Aug 2017
Kozuka Ritsuzo, Hai Hoang, Teranishi Yuga, Motoyama Hiroyuki, Kawamura Etsushi, Hagihara Atsushi, Uchida-Kobayashi Sawako, Morikawa Hiroyasu, Enomoto Masaru, Murakami Yoshiki, Kawada Norifumi, Tamori Akihiro
Abstract excerpt
BACKGROUND AND AIM: It is unclear whether polymorphism in the inosine triphosphatase (ITPA) gene correlates to the reduction in hemoglobin (Hb) concentrations during sofosbuvir (SOF) and ribavirin (RBV) therapy. This study investigated the effects of the ITPA polymorphism on Japanese patients with chronic hepatitis C virus genotype 2 infection treated with SOF/RBV therapy. METHODS: In 106 patients treated with...
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