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Article

The impact of inosine triphosphatase variants on hemoglobin level and sustained virologic response of chronic hepatitis C in Korean.

Journal of Korean medical science - 1 Aug 2013

Kim Ju Seung, Ahn Sung-Min, Jung Young Kul, Kwon Oh Sang, Kim Yun Soo, Choi Duck Joo, Kim Ju Hyun

Abstract excerpt

TWO VARIANTS OF THE INOSINE TRIPHOSPHATASE (ITPA: rs1127354, rs7270101) gene cause ITPA deficiency and protect against the hemolytic toxicity of ribavirin. We investigated the clinical significance of ITPA variants in Korean patients treated with pegylated interferon (PEG-IFN) plus ribavirin. Of the 133 patients, 108 were CC and 25 were non-CC at rs1127354 (groups A and B, respectively). On the other hand, at...

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Source

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Identifiers

PMID: 23960450
DOI: 10.3346/jkms.2013.28.8.1213
PMCID: PMC3744711

Genes

ITPA

Provenance

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The impact of inosine triphosphatase variants on hemoglobin level and sustained virologic response of chronic hepatitis C in Korean.PMID 23960450Read ↗

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