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Article

Polymorphism of the inosine triphosphate pyrophosphatase gene predicts ribavirin-induced anemia in chronic hepatitis C patients.

Molecular medicine reports - 1 Feb 2012

Nishimura Takashi, Osaki Rie, Shioya Makoto, Imaeda Hirotsugu, Aomatsu Tomoki, Takeuchi Takayuki, Okumura Yoshiaki, Fujiyama Yoshihide, Andoh Akira

Abstract excerpt

Ribavirin (RBV)-induced anemia is a serious side effect of pegylated interferon (PEG-IFN) plus RBV therapy which is the standard care most effective for hepatitis C virus (HCV) infection. In the present study, we investigated the association of inosine triphosphate pyrophosphatase (ITPA) genotypes with RBV-induced hemoglobin (Hb) reduction in HCV patients treated with PEG-IFN/RBV therapy. The genotypes of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22052220
DOI: 10.3892/mmr.2011.659

Genes

ITPA

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