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Article

Disruption of the Ang II type 1 receptor promotes longevity in mice.

The Journal of clinical investigation - 1 Mar 2009

Benigni Ariela, Corna Daniela, Zoja Carla, Sonzogni Aurelio, Latini Roberto, Salio Monica, Conti Sara, Rottoli Daniela, Longaretti Lorena, Cassis Paola, Morigi Marina, Coffman Thomas M, Remuzzi Giuseppe

Abstract excerpt

The renin-angiotensin system plays a role in the etiology of hypertension and the pathophysiology of cardiac and renal diseases in humans. Ang II is the central product of this system and is involved in regulating immune responses, inflammation, cell growth, and proliferation by acting through Ang II type 1 receptors (AT1 and AT2). Here, we show that targeted disruption of the Agtr1a gene that encodes AT1A...

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Identifiers

PMID: 19197138
DOI: 10.1172/JCI36703
PMCID: PMC2648681

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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