Article
The Influence of VKORC1 Polymorphisms on Warfarin Doses in Thai Patients with Deep Vein Thrombosis.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet - 1 Jun 2015
Sermsathanasawadi Nuttawut, Sritongsathian Chukij, Pongrattanaman Nunthapol, Praditsuktavorn Banjerd, Hongku Kiattisak, Wongwanit Chumpol, Ruangsetakit Chanean, Chinsakchai Khamin, Mutirangura Pramook, Poungvarin Naravat
Abstract excerpt
BACKGROUND: Polymorphisms in cytochrome P450 2C9 and vitamin K epoxide reductase complex, subunit 1 genes (CYP2C9 and VKORC1, respectively) were previously shown to affect the warfarin dose required in anticoagulant therapy of deep vein thrombosis (DVT). However, little is known about the role of these genetic variants in the Thai population. OBJECTIVE: To identify the effect of CYP2C9 and VKORC1 genetic variants...
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