Article
Prevalence of CYP2C9 and VKORC1 mutation in patients with valvular heart disease in northern Thailand.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet - 1 Dec 2009
Kuanprasert Srun, Dettrairat Sakchai, Palacajornsuk Poonsub, Kunachiwa Warunee, Phrommintikul Arintaya
Abstract excerpt
BACKGROUND: Warfarin has been widely used for the prevention and treatment of thromboembolism. Warfarin therapy depends on interaction between physiological, environmental, and genetic factors. Vitamin K epoxide reductase (VKORC1) and cytochrome P450 2C9 (CYP2C9) enzyme conjointly determine the w...
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