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Article

Failure to Target RANKL Signaling Through p38-MAPK Results in Defective Osteoclastogenesis in the Microphthalmia Cloudy-Eyed Mutant.

Journal of cellular physiology - 1 Mar 2016

Carey Heather A, Bronisz Agnieszka, Cabrera Jennifer, Hildreth Blake E, Cuitiño Maria, Fu Qi, Ahmad Asrar, Toribio Ramiro E, Ostrowski Michael C, Sharma Sudarshana M

Abstract excerpt

The Microphthalmia-associated transcription factor (MITF) is a basic helix-loop-helix leucine zipper family factor that is essential for terminal osteoclast differentiation. Previous work demonstrates that phosphorylation of MITF by p38 MAPK downstream of Receptor Activator of NFkB Ligand (RANKL) signaling is necessary for MITF activation in osteoclasts. The spontaneous Mitf cloudy eyed (ce) allele results in...

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Source

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Identifiers

PMID: 26218069
DOI: 10.1002/jcp.25108
PMCID: PMC4664053

Genes

MITF
FUS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Failure to Target RANKL Signaling Through p38-MAPK Results in Defective Osteoclastogenesis in the Microphthalmia Cloudy-Eyed Mutant.PMID 26218069Read ↗

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