Gene alterations in epigenetic modifiers and JAK-STAT signaling are frequent in breast implant-associated ALCL.

doi:10.1182/blood.2019001904

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Article

Gene alterations in epigenetic modifiers and JAK-STAT signaling are frequent in breast implant-associated ALCL.

Blood - 30 Jan 2020

Laurent Camille, Nicolae Alina, Laurent Cécile, Le Bras Fabien, Haioun Corinne, Fataccioli Virginie, Amara Nadia, Adélaïde José, Guille Arnaud, Schiano Jean-Marc, Tesson Bruno, Traverse-Glehen Alexandra, Chenard Marie-Pierre, Mescam Lénaïg, Moreau Anne, Chassagne-Clement Catherine, Somja Joan, Escudié Frédéric, André Marc, Martin Nadine, Lacroix Laetitia, Lemonnier François, Hamy Anne-Sophie, Reyal Fabien, Bannier Marie, Oberic Lucie, Prade Nais, Frénois François-Xavier, Beldi-Ferchiou Asma, Delfau-Larue Marie-Helene, Bouabdallah Reda, Birnbaum Daniel, Brousset Pierre, Xerri Luc, Gaulard Philippe

Abstract excerpt

The oncogenic events involved in breast implant-associated anaplastic large cell lymphoma (BI-ALCL) remain elusive. To clarify this point, we have characterized the genomic landscape of 34 BI-ALCLs (15 tumor and 19 in situ subtypes) collected from 54 BI-ALCL patients diagnosed through the French Lymphopath network. Whole-exome sequencing (n = 22, with paired tumor/germline DNA) and/or targeted deep sequencing (n...

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Identifiers

PMID: 31774495
DOI: 10.1182/blood.2019001904
PMCID: PMC7059458

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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