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Article

Recurrent numerical aberrations of JAK2 and deregulation of the JAK2-STAT cascade in lymphomas.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Mar 2009

Meier Cecile, Hoeller Sylvia, Bourgau Caroline, Hirschmann Petra, Schwaller Juerg, Went Philip, Pileri Stefano A, Reiter Andreas, Dirnhofer Stephan, Tzankov Alexandar

Abstract excerpt

The Janus kinase 2 (JAK2)-signal transducers and activators of transcription (STAT) pathway plays an important role in hematological malignancies. Mutations and translocations of the JAK2 gene, mapped at 9p24, lead to constitutive activation of JAK2 and its downstream targets. The presence of JAK2 mutations in lymphomas has been addressed in larger cohorts, but there are little systemic data on numerical and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19136931
DOI: 10.1038/modpathol.2008.207

Genes

JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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