Article
Next generation sequencing of breast implant-associated anaplastic large cell lymphomas reveals a novel STAT3-JAK2 fusion among other activating genetic alterations within the JAK-STAT pathway.
The breast journal - 1 Apr 2021
Quesada Andrés E, Zhang Yanming, Ptashkin Ryan, Ho Caleb, Horwitz Steven, Benayed Ryma, Dogan Ahmet, Arcila Maria E
Abstract excerpt
Breast implant associated anaplastic large cell lymphoma (BIA-ALCL) is a distinct type of ALCL, and a new provisional entity by the 2016 revision of the World Health Organization (WHO) classification of tumors of hematopoietic and lymphoid tissues. In contrast to systemic and primary cutaneous ALCLs, BIA-ALCLs have been genetically characterized by the absence of fusions and frequent activation of the JAK-STAT3...
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