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Article

Emerging roles for IL-11 signaling in cancer development and progression: Focus on breast cancer

14 Jul 2015

Abstract excerpt

Interleukin (IL)-11 is a member of the IL-6 family of cytokines that is defined by the shared use of the GP130 signal transducing receptor subunit. In addition of its long recognized activities as a hemopoietic growth factor, IL-11 has an emerging role in epithelial cancer biology. Through the activation of the GP130-Janus kinase signaling cascade and associated transcription factor STAT3, IL-11 can confer many...

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Identifiers

PMID: 26209885
DOI: 10.1016/j.cytogfr.2015.07.015

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