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The role of the interleukin (IL)-6/IL-6 receptor axis in cancer

22 Nov 2018

Abstract excerpt

Interleukin-6 (IL-6) is a pleiotropic cytokine that activates a classic signalling pathway upon binding to its membrane-bound receptor (IL-6R). Alternatively, IL-6 may 'trans-signal' in a manner that is facilitated by its binding to a soluble derivative of the IL-6 receptor (sIL-6R). Resultant signal transduction is, respectively, driven by the association of IL-6/IL-6R or IL-6/sIL-6R complex with the...

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PMID: 30467123
DOI: 10.1042/bst20180136

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