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Profiling protein post-translational modifications in plasma-derived extracellular vesicles as fingerprints for breast cancer subtypes

24 Jul 2026

Abstract excerpt

Addressing tumor heterogeneity in breast cancer (BC) research is crucial, given the distinct subtypes like triple-negative (TN), luminal A/B (LAB), and HER2, requiring precise differentiation for effective treatment. This study introduces a non-invasive method by analyzing post-translationally modified proteins in plasma extracellular vesicles (EVs), which play a role in immune regulation and intercellular...

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PMID: 40894036
DOI: 10.1186/s13059-026-04212-w

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