Genome-wide copy-number-variation study identified a susceptibility gene, UGT2B17, for osteoporosis.

doi:10.1016/j.ajhg.2008.10.006

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Genome-wide copy-number-variation study identified a susceptibility gene, UGT2B17, for osteoporosis.

American journal of human genetics - 1 Dec 2008

Yang Tie-Lin, Chen Xiang-Ding, Guo Yan, Lei Shu-Feng, Wang Jin-Tang, Zhou Qi, Pan Feng, Chen Yuan, Zhang Zhi-Xin, Dong Shan-Shan, Xu Xiang-Hong, Yan Han, Liu Xiaogang, Qiu Chuan, Zhu Xue-Zhen, Chen Teng, Li Meng, Zhang Hong, Zhang Liang, Drees Betty M, Hamilton James J, Papasian Christopher J, Recker Robert R, Song Xiao-Ping, Cheng Jing, Deng Hong-Wen

Abstract excerpt

Osteoporosis, a highly heritable disease, is characterized mainly by low bone-mineral density (BMD), poor bone geometry, and/or osteoporotic fractures (OF). Copy-number variation (CNV) has been shown to be associated with complex human diseases. The contribution of CNV to osteoporosis has not been determined yet. We conducted case-control genome-wide CNV analyses, using the Affymetrix 500K Array Set, in 700...

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PMID: 18992858
DOI: 10.1016/j.ajhg.2008.10.006
PMCID: PMC2667994

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