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Article

The multiple facets of alpha-1-antitrypsin.

1 Jun 2015

Abstract excerpt

Alpha-1-antitrypsin (AAT) is recognised as a potent inhibitor of serine proteinases. Genetic deficiency is associated with several neutrophilic diseases including severe emphysema. This is believed to reflect the loss of inhibition of neutrophilic serine proteinases that then result in local tissue damage (the proteinase/antiprotease hypothesis). In recent years the role of AAT in the control of inflammatory and...

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PMID: 26207223
DOI: 10.3978/j.issn.2305-5839.2015.04.25

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