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Alpha 1 Anti-Trypsin: One Protein, Many Functions

1 Jun 2012

Abstract excerpt

α-1 anti-trypsin (AAT) is the most abundant circulating serine protease inhibitor (serpin) and an acute phase reactant. Systemic deficiency in AAT (AATD) due to genetic mutations can result in liver failure and chronic lung disease such as emphysema. Considered the prototypic serpin, the emphysema observed in patients with AATD, consisting of progressive destruction of the alveoli and small airway structures,...

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PMID: 22697349
DOI: 10.2174/156652412801318755

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