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Article

Neonatal Progesterone Programs Adult Uterine Responses to Progesterone and Susceptibility to Uterine Dysfunction.

Endocrinology - 1 Oct 2015

Dhakal Pramod, Rumi M A Karim, Kubota Kaiyu, Chakraborty Damayanti, Chien Jeremy, Roby Katherine F, Soares Michael J

Abstract excerpt

In this report, we investigated the consequences of neonatal progesterone exposure on adult rat uterine function. Female pups were subcutaneously injected with vehicle or progesterone from postnatal days 3 to 9. Early progesterone exposure affected endometrial gland biogenesis, puberty, decidualization, and fertility. Because decidualization and pregnancy success are directly linked to progesterone action on the...

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Identifiers

PMID: 26204463
DOI: 10.1210/en.2015-1397
PMCID: PMC4588825

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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