Article
Analgesic exposure in pregnant rats affects fetal germ cell development with inter-generational reproductive consequences.
Scientific reports - 27 Jan 2016
Dean Afshan, van den Driesche Sander, Wang Yili, McKinnell Chris, Macpherson Sheila, Eddie Sharon L, Kinnell Hazel, Hurtado-Gonzalez Pablo, Chambers Tom J, Stevenson Kerrie, Wolfinger Elke, Hrabalkova Lenka, Calarrao Ana, Bayne Rosey Al, Hagen Casper P, Mitchell Rod T, Anderson Richard A, Sharpe Richard M
Abstract excerpt
Analgesics which affect prostaglandin (PG) pathways are used by most pregnant women. As germ cells (GC) undergo developmental and epigenetic changes in fetal life and are PG targets, we investigated if exposure of pregnant rats to analgesics (indomethacin or acetaminophen) affected GC development and reproductive function in resulting offspring (F1) or in the F2 generation. Exposure to either analgesic reduced F1...
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