Article

Maternal progesterone signaling establishes lifelong oral homeostasis

2026-08-16

Abstract excerpt

Pregnancy is accompanied by profound endocrine remodeling, yet the mechanisms by which maternal hormonal signals establish long-term tissue homeostasis remain largely unknown. Here we identify maternal progesterone signaling as a developmental cue that establishes lifelong oral homeostasis through a hormone–lipid–microbiome axis. We show that the membrane progesterone receptor mPRδ is selectively expressed in the...

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Literature Corpus work: 9683a6cd-a2e8-54ba-91be-ea9e454a3ea9
DOI: 10.64898/2026.08.10.743932

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