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Article

Proteomic and Metabolic Analyses of S49 Lymphoma Cells Reveal Novel Regulation of Mitochondria by cAMP and Protein Kinase A.

The Journal of biological chemistry - 4 Sept 2015

Wilderman Andrea, Guo Yurong, Divakaruni Ajit S, Perkins Guy, Zhang Lingzhi, Murphy Anne N, Taylor Susan S, Insel Paul A

Abstract excerpt

Cyclic AMP (cAMP), acting via protein kinase A (PKA), regulates many cellular responses, but the role of mitochondria in such responses is poorly understood. To define such roles, we used quantitative proteomic analysis of mitochondria-enriched fractions and performed functional and morphologic studies of wild-type (WT) and kin(-) (PKA-null) murine S49 lymphoma cells. Basally, 75 proteins significantly differed...

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Identifiers

PMID: 26203188
DOI: 10.1074/jbc.M115.658153
PMCID: PMC4571978

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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