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Article

Oxidative stress induced mitochondrial protein kinase A mediates cytochrome c oxidase dysfunction.

PloS one - 1 Jan 2013

Srinivasan Satish, Spear Joseph, Chandran Karunakaran, Joseph Joy, Kalyanaraman Balaraman, Avadhani Narayan G

Abstract excerpt

Previously we showed that Protein kinase A (PKA) activated in hypoxia and myocardial ischemia/reperfusion mediates phosphorylation of subunits I, IVi1 and Vb of cytochrome c oxidase. However, the mechanism of activation of the kinase under hypoxia remains unclear. It is also unclear if hypoxic stress activated PKA is different from the cAMP dependent mitochondrial PKA activity reported under normal physiological...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24130844
DOI: 10.1371/journal.pone.0077129
PMCID: PMC3795003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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