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Article

CRISPR-Cas9-Mediated Genome Editing in Leishmania donovani

21 Jul 2015

Abstract excerpt

UNLABELLED: The prokaryotic CRISPR (clustered regularly interspaced short palindromic repeat)-Cas9, an RNA-guided endonuclease, has been shown to mediate efficient genome editing in a wide variety of organisms. In the present study, the CRISPR-Cas9 system has been adapted to Leishmania donovani, a protozoan parasite that causes fatal human visceral leishmaniasis. We introduced the Cas9 nuclease into L. donovani...

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PMID: 26199327
DOI: 10.1128/mbio.00861-15

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