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Article

A Role for Autoinhibition in Preventing Dimerization of the Transcription Factor ETS1.

The Journal of biological chemistry - 4 Sept 2015

Samorodnitsky Daniel, Szyjka Courtney, Koudelka Gerald B

Abstract excerpt

ETS1 is the archetype of the ETS transcription factor (TF) family. ETS TFs share a DNA-binding domain, the ETS domain. All ETS TFs recognize a core GGA(A/T) binding site, and thus ETS TFs are found to redundantly regulate the same genes. However, each ETS TF has unique targets as well. One prevailing hypotheses explaining this duality is that protein-protein interactions, including homodimerization, allow each...

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Identifiers

PMID: 26195629
DOI: 10.1074/jbc.M115.671339
PMCID: PMC4571961

Genes

ETS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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