Article
Characterization of an intramolecular protein-protein interaction in c-Ets1 and its viral homologue v-Ets.
Oncology reports - 1 Aug 2007
Schmidt Melanie, Schmidt André Michael, Dietl Johannes, Kammerer Ulrike
Abstract excerpt
The proto-oncoprotein c-Ets1 is a well-known transcription factor that belongs to the Ets family and plays a role in haematopoietic differentiation, angiogenesis, and carcinogenesis. Ets family members share a unique DNA binding domain, the Ets domain, and are known to control DNA binding activity and transcriptional activation by autoinhibition. In c-Ets1 the DNA binding domain as well as N-terminal and...
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