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Article

Structural basis of multimer-mediated mayhem.

Cancer cell - 1 Apr 2006

Sitwala Kajal V, Hess Jay L

Abstract excerpt

Oligomerization of AML1-ETO contributes to leukemogenesis through obscure mechanisms. In this issue of Cancer Cell, Bushweller and colleagues show the crystal structure of the ETO NHR2 domain to be a tetramer. Tetramer formation is important for maturation arrest and self-renewal, and gene expression is altered in the absence of self-association. Loss of oligomer formation disrupts interactions between AML1-ETO...

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Identifiers

PMID: 16616328
DOI: 10.1016/j.ccr.2006.03.022

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