Article
Serum flecainide S/R ratio reflects the CYP2D6 genotype and changes in CYP2D6 activity.
Drug metabolism and pharmacokinetics - 1 Aug 2015
Doki Kosuke, Sekiguchi Yukio, Kuga Keisuke, Aonuma Kazutaka, Homma Masato
Abstract excerpt
The aims of this study were to clarify whether the ratio of S- to R-flecainide (S/R ratio) in the serum flecainide concentration was associated with the stereoselectivity of flecainide metabolism, and to investigate the effects of the cytochrome P450 (CYP) 2D6 (CYP2D6) genotype and CYP2D6 inhibitor on the serum flecainide S/R ratio. In vitro studies using human liver microsomes and cDNA-expressed CYP isoforms...
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