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Article

CYP2D6 genotype affects age-related decline in flecainide clearance: a population pharmacokinetic analysis.

Pharmacogenetics and genomics - 1 Nov 2012

Doki Kosuke, Homma Masato, Kuga Keisuke, Aonuma Kazutaka, Kohda Yukinao

Abstract excerpt

OBJECTIVE: To investigate the association between age-related decline in flecainide clearance and CYP2D6 genotype, we conducted a population pharmacokinetic analysis of flecainide using routine therapeutic drug monitoring data. METHODS: Population pharmacokinetic analysis was performed on retrospective data from 163 genotyped patients treated with oral flecainide for supraventricular tachyarrhythmias. The CYP2D6...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22941032
DOI: 10.1097/FPC.0b013e3283588fe5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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