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Article

CYP2D6 Genotype Information to Guide Pimozide Treatment in Adult and Pediatric Patients

15 Sept 2012

Abstract excerpt

Article AbstractObjective: The occurrence of pimozide-induced arrhythmias is concentration dependent. Hence, it is important for prescribers to consider causes of increased pimozide exposure. This article summarizes the US Food and Drug Administration's (FDA's ) review of drug interaction and pharmacogenomic studies and discusses pharmacokinetic simulations we performed to develop new cytochrome P450 2D6 (CYP2D6)...

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Share to Carcinogens and Genotoxicity Assessment
Share to Cardiac electrophysiology and arrhythmias
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PMID: 23059146
DOI: 10.4088/jcp.11m07572

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