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Article

Human actin mutations associated with hypertrophic and dilated cardiomyopathies demonstrate distinct thin filament regulatory properties in vitro.

Journal of molecular and cellular cardiology - 1 Feb 2010

Debold Edward P, Saber Walid, Cheema Yaser, Bookwalter Carol S, Trybus Kathleen M, Warshaw David M, Vanburen Peter

Abstract excerpt

Two cardiomyopathic mutations were expressed in human cardiac actin, using a Baculovirus/insect cell system; E99K is associated with hypertrophic cardiomyopathy whereas R312H is associated with dilated cardiomyopathy. The hypothesis that the divergent phenotypes of these two cardiomyopathies are associated with fundamental differences in the molecular mechanics and thin filament regulation of the underlying actin...

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Source

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Identifiers

PMID: 19799913
DOI: 10.1016/j.yjmcc.2009.09.014
PMCID: PMC2813351

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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