Article
Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation.
Developmental cell - 1 Jul 2003
Casenghi Martina, Meraldi Patrick, Weinhart Ulrike, Duncan Peter I, Körner Roman, Nigg Erich A
Abstract excerpt
In animal cells, most microtubules are nucleated at centrosomes. At the onset of mitosis, centrosomes undergo a structural reorganization, termed maturation, which leads to increased microtubule nucleation activity. Centrosome maturation is regulated by several kinases, including Polo-like kinase 1 (Plk1). Here, we identify a centrosomal Plk1 substrate, termed Nlp (ninein-like protein), whose properties suggest...
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